Half-titanocene 5-t-butyl-2-(1-(arylimino)methyl)quinolin-8-olate chlorides: Synthesis, characterization and ethylene (co-) polymerization behavior

A series of half-titanocene chloride complexes bearing 5-t-butyl-2-(1-(arylimino)methyl)quinolin-8-olate ligands (L), CpTiLCl₂, has been synthesized in acceptable yields by the stoichiometric reaction of CpTiCl₃ with the respective potassium 5-t-butyl-2-(1-(arylimino)methyl)quinolin-8-olate. All half-titanocene complexes were fully characterized by elemental analysis and NMR spectroscopy, and the molecular structures of the representative complexes C1 and C2 were confirmed as pseudo octahedral at titanium by single-crystal X-ray diffraction. When activated with methylaluminoxane (MAO) or modified methylaluminoxane (MMAO), all titanium complexes exhibited good activities (up to 4.8 × 10⁵ g mol⁻¹(Ti) h⁻¹) towards ethylene polymerization. The obtained polyethylene exhibited ultra-high molecular weight (up to 11.82 × 10⁵ g mol⁻¹) with narrow polydispersity. Furthermore, effective co-polymerization of ethylene with 1-hexene or 1-octene was achieved with several percentages of co-monomer incorporation in the resultant polyethylenes

Biphenyl-bridged 6-(1-aryliminoethyl)-2-iminopyridyl-cobalt complexes: synthesis, characterization and ethylene polymerization behavior

A series of biphenyl-bridged 6-(1-aryliminoethyl)-2-iminopyridine derivatives reacted with cobalt dichloride in dichloromethane/ethanol to afford the corresponding binuclear cobalt complexes. The cobalt complexes were characterized by FT-IR spectroscopy and elemental analysis, and the structure of a representative complex was confirmed by single-crystal X-ray diffraction. Upon activation with either MAO or MMAO, these cobalt complexes performed with high activities of up to 1.2 × 10⁷ g (mol of Co)⁻¹ h⁻¹ in ethylene polymerization, which represents one of the most active cobalt-based catalytic systems in ethylene reactivity. These biphenyl-bridged bis(imino)pyridylcobalt precatalysts exhibited higher activities than did their mononuclear bis(imino)pyridylcobalt precatalyst counterparts, and more importantly, the binuclear precatalysts revealed a better thermal stability and longer lifetimes. The polyethylenes obtained were characterized by GPC, DSC, and high-temperature NMR spectroscopy and mostly possessed unimodal and highly linear features

nCD64 index as a novel inflammatory indicator for the early prediction of prognosis in infectious and non-infectious inflammatory diseases: An observational study of febrile patients

BackgroundGenerally, febrile patients admitted to the Department of Infectious Diseases, Fudan University Affiliated Huashan Hospital, China may eventually be diagnosed as infectious (ID) or non-infectious inflammatory diseases (NIID). Furthermore, mortality from sepsis remains incredibly high. Thus, early diagnosis and prognosis evaluation of sepsis is necessary. Here, we investigated neutrophil (n)CD64 index profile in a cohort of febrile patients and explored its diagnostic and prognostic value in ID and NIID.MethodsThis observational cohort study enrolled 348 febrile patients from the Emergency Department and Department of Infectious Diseases. nCD64 index were detected using flow cytometry, and dynamically measured at different timepoints during follow-up. Procalcitonin (PCT), C-reactive protein (CRP), and ferritin levels were measured routinely. Finally, the diagnostic and prognostic value of nCD64 index were evaluated by receiver operating characteristic (ROC) analysis and Kaplan-Meier curve analysis.ResultsOf included 348 febrile patients, 238, 81, and 29 were categorized into ID, NIID, and lymphoma groups, respectively. In ID patients, both SOFA score and infection site had impact on nCD64 index expression. In NIID patients, adult-onset Still’s disease patients had the highest nCD64 index value, however, nCD64 index couldn’t distinguish between ID and NIID. Regardless of the site of infection, nCD64 index was significantly higher in bacterial and viral infections than in fungal infections, but it could not discriminate between bacterial and viral infections. In bloodstream infections, gram-negative (G-) bacterial infections showed an obvious increase in nCD64 index compared to that of gram-positive (G+) bacterial infections. nCD64 index has the potential to be a biomarker for distinguishing between DNA and RNA virus infections. The routine measurement of nCD64 index can facilitate septic shock diagnosis and predict 28-day hospital mortality in patients with sepsis. Serial monitoring of nCD64 index in patients with sepsis is helpful for evaluating prognosis and treatment efficacy. Notably, nCD64 index is more sensitive to predict disease progression and monitor glucocorticoid treatment in patients with NIID.ConclusionsnCD64 index can be used to predict 28-day hospital mortality in patients with sepsis and to evaluate the prognosis. Serial determinations of nCD64 index can be used to predict and monitor disease progression in patients with NIID